Extraction mechanism of ultrasound assisted extraction and its effect on higher yielding and purity of artemisinin crystals from Artemisia annua L. leaves
Smain Chemat , Abdallah Aissa, Abdenour Boumechhour, Omar Arous, Hamid Ait-Amar
Jun 2016
Ultrasonics Sonochemistry
Abstract : 

This study proposes an ultrasound-horn system for the extraction of a natural active compound “artemisinin” from Artemisia annua L. leaves as an alternative to hot maceration technique. Ultrasound leaching improves artemisinin recovery at all temperatures where only ten minutes is required to recover 70% (4.42 mg g−1) compared to 60 min of conventional hot leaching for the same yield. For instance, ultrasound treatment at 30 °C produced a higher yield than the one obtained by conventional maceration at 40 °C. Kinetic study suggests that the extraction pattern can be assimilated, during the first ten minutes, to a first order steady state, from which activation energy calculations revealed that each gram of artemisinin required 7.38 kJ in ultrasound versus 10.3 kJ in the conventional system. Modeling results indicate the presence of two extraction stages, a faster stage with a diffusion coefficient of 19 × 10−5 cm2 min−1 for ultrasound technique at 40 °C, seven times higher than the conventional one; and a second deceleration stage similar for both techniques with diffusion coefficient ranging from 1.7 to 3.1 × 10−5 cm2 min−1. It is noted that the efficient ultrasound extraction potential implies extraction of higher amount of co-metabolites so low artemisinin crystal purity is engendered but a combination with a purification step using activated charcoal and celite adsorbents produced crystals with comparable purity for conventional and ultrasound samples.


The soil from an industrial area in Algeria was contaminated with Cr (8370 mg kg−1), Ni (1135 mg kg−1) and zinc (1200 mg kg−1).
Mixed oxide MnO/Mn3O4 was successfully incorporated into NiAl hydrotalcite derived systems following an ionic excha
The preparation and characterization of the hetero-junctions x%Bi2S3/TiO2 (x = 1, 5, 10 and 15%) and their photocatalytic performances for the degr
A one-pot diastereoselective base-catalyzed Michael-initiated ring-closure (MIRC) of activated methyl ketones with 3-bromochromones to give c
The modified carbon paste electrode with Ru(III) complex was studied as a novel sensor for the determination of nitrite.
Problems related to water mixing becoming more important, especially when it comes to evaluate the impact of a domestic, industrial or
This study proposes an ultrasound-horn system for the extraction of a natural active compound “artemisinin” from Artemisia annua