Bis(4-hydroxy-2H-chromen-2-one) Coumarin Induces Apoptosis in MCF-7 Human Breast Cancer Cells Through Aromatase Inhibition

Bis(4-hydroxy-2H-chromen-2-one) Coumarin Induces Apoptosis in MCF-7 Human Breast Cancer Cells Through Aromatase Inhibition

Publication Scientifique, Publication Scientifique Division Santé
LAMIA HAMDAN RAMDANI1,2⇑, OUALID TALHI1,3, CAROLINE DECOMBAT2, MARION VERMERIE2, ALEXANDRE BERRY2, ARTUR SILVA3, KHALDOUN BACHARI1, MARIE-PAULE VASSON2,4, LAETITIA DELORT2,* and FLORENCE CALDEFIE-CHÉZET2,5,* Author Affiliations 1-Scientific and Technical Research Center in Physico-Chemical Analysis (CRAPC), Tipaza, Algeria 2-Clermont Auvergne University, INRA, UNH, Human Nutrition unit, CRNH Auvergne, Clermont Ferrand, France 3-Organic Chemistry, Natural Products and Agrifood (QOPNA), Department of Chemistry & QOPNA, University of Aveiro, Aveiro, Portugal 4-Anticancer Center Jean-Perrin, Clermont Ferrand, France 5-CLARA, Lyon Auvergne Rhone Alpes canceropole, Lyon, France Correspondence to: Lamia Hamdan Ramdani, Clermont Auvergne University, INRA, UNH, Human Nutrition Unit, CRNH Auvergne, F-63000 Clermont-Ferrand, France. Tel: +213 799423134, e-mail: lamia_pharm@yahoo.fr Abstract Aim: The present investigation aimed to examine the therapeutic potential of the new coumarin derivative bis(4-hydroxy-2H-chromen-2-one) coumarin (4HC) against breast cancer. Materials and Methods: For this purpose,…
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