Determination of trace elements Fe, cu and Zn in the Algerian cancerous plasma using X‐ray fluorescence (XRF)

L. LahmarM.E.A. BenamarM.A. MelziC.H. MelkaouY. Mabdoua

First published: 14 November 2019


Cancers are among the leading causes of morbidity and mortality in the world. The purpose of this study was to conduct a survey on the effect of minerals on cancer risk in the Algerian population. One hundred and seventy‐eight plasma samples were used to analyze the concentrations of iron (Fe), copper (Cu), and zinc (Zn) in cancerous patients and also in healthy subjects using the X‐ray florescence technique (XRF). Samples were classified according to the age and gender of the donors. An empirical formula was developed for the concentration of Zinc, Copper and Iron in cancer patients according to the age. The averages iron, copper and zinc concentrations in mg/kg for control and Cancer disease groups were (1493 ± 105; 1496 ± 86), (1172 ± 229; 1078 ± 283) and (1266 ± 202; 1344 ± 208) respectively. The ANOVA One‐Way test was applied. For both genders of control and cancer disease groups it shows a significant decrease rate of copper for global and female gender and a significant increase rate of zinc for global and male gender (p < 0.05). The results indicate that the Cu and Zn concentration could show helpful tools for diagnosis and preventive treatment of cancer diseases.

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